Selangor Journal
Doses of the Pfizer – BioNTech vaccine against Covid-19 are pictured at a booster clinic for 12 to 17-year-olds in Lansdale, Pennsylvania, the United States, on January 9, 2022. — Picture by REUTERS

New study shows Covid infection weakens immune-cell response to vaccination

LOS ANGELES, March 21 — The magnitude and quality of a key immune cell’s response to vaccination with two doses of the Pfizer-BioNTech Covid-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, according to a new study published on Monday.

The study, co-funded by the US National Institutes of Health, also found the level of this key immune cell that targets the SARS-CoV-2 spike protein was substantially lower in unvaccinated people with Covid-19 than in vaccinated people who had never been infected, said Xinhua.

The study, published in the journal Immunity, suggests that the virus damages important immune-cell response.

The new findings highlight the need to develop vaccination strategies to specifically boost antiviral CD8+ T cell responses in people previously infected with SARS-CoV-2, according to the researchers.

— Bernama

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